Christina Applegate has been discharged from the hospital after a stay that began in late March, a grueling stretch that underscores the relentless toll of her battle with multiple sclerosis.

An unnamed insider told TMZ that the 54-year-old actress is back home and "doing well" following the extended hospitalization, Page Six reported Monday. No specific hospital or city was identified, and the exact reason for the late March admission remains unclear. Her representative was not available for comment on the discharge.

Applegate, best known for her role as Kelly Bundy on "Married... With Children" and more recently for the Netflix series "Dead to Me," was diagnosed with MS in 2021. The Mayo Clinic defines the disease as a condition of the brain and spinal cord that can cause numbness, weakness, trouble walking, and vision changes. Since her diagnosis, Applegate's health has deteriorated sharply, and publicly.

More than 30 hospitalizations since her MS diagnosis

The late March admission was far from Applegate's first. She has been hospitalized "upwards of 30 times" due to MS-related complications including vomiting and diarrhea, the New York Post reported last year. In August 2025, she revealed on her "MeSsy" podcast that she had been hospitalized with a kidney infection that spread to both kidneys, requiring intravenous antibiotics. That infection began while she was visiting family in Europe and worsened after her flight home.

On the podcast, Applegate described the pain in blunt terms, she was "screaming" from it. She did not sugarcoat the emotional weight, either.

"I'm holding in a bag o' tears right now."

At the time of the late March hospitalization, her representative offered a brief statement to Page Six:

"She's had a long history of complicated medical conditions that she has been refreshingly open about."

The rep declined to confirm what medical treatments Applegate received during her nearly four-month stay.

Applegate posted from the hospital, telling fans she was getting stronger

A few days after news of the hospitalization became public, Applegate addressed her fans on Instagram. She did not dwell on specifics but struck a defiant tone.

"Health issues are a constant for me, but I'm a strong chick and I'm getting stronger and better every day."

She added that she was "taking a moment to focus on my health, but I'll be back with more to say soon enough."

David Faustino, who played her on-screen brother Bud Bundy on "Married... With Children" from 1987 to 1997, gave an update on Applegate's condition to Us Weekly in June. He described the situation honestly but said Applegate's personality remains intact.

"It's been very hard for her, but she does keep her humor. She gets through this with some humor, and that's kind of her way that she moves through it."

Faustino said he stays close to Applegate through regular visits, texting, and check-ins.

Her daily routine had already shrunk to one task she refused to give up

Before the late March hospitalization, Applegate had revealed in February that she was largely confined to her bed. But she told People magazine that she still insisted on driving her 15-year-old daughter Sadie to school every day, even when it cost her physically.

"I want to take her; it's my favorite thing to do. It's the only time we have together by ourselves. I tell myself, 'Just get her there safely and get home so you can get back into bed.' And that's what I do."

The toll on Sadie has been visible, too. Applegate has said her daughter admitted to missing who Applegate was before the MS diagnosis. Applegate did not soften her own reaction to that conversation.

"That is just like a knife to the heart because I miss who I was before I got sick, too. Very much. Every day of my life is at such a loss."

Applegate shares Sadie with her husband, Martyn LeNoble.

Beyond "Married... With Children," Applegate's career includes films like "Bad Moms" and "The Sweetest Thing." She continues to co-host the "MeSsy" podcast, where she has been unusually candid about the realities of living with a progressive autoimmune disease, the kind of candor most public figures avoid.

No details have emerged about what comes next medically. Whether the discharge signals meaningful improvement or simply a pause between crises remains an open question. Applegate's rep has offered no update on her current condition beyond the insider's report that she is "doing well."

Four months in a hospital bed is not a headline. It is a life reduced to its smallest possible frame, and Applegate, to her credit, has refused to pretend otherwise.